Protein Details: Gamma-aminobutyric acid receptor subunit beta

Protein ID

ICDB_Pro_0446

Protein Name

Gamma-aminobutyric acid receptor subunit beta

Gene Name

Organism

Lymnaea stagnalis (Great pond snail) (Helix stagnalis)

Length

499 amino acids

AlphaFoldDB

AF-P26714-F1-model_v4.pdb

Function

GABA; an inhibitory neurotransmitter; mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Sequence

MWGIIVPFFSASLMCSLVAVVRCQQDTDHFANVTNTIDSLLKGYDIRLRPSFGGAPLEIGIEVILASFDSISEVDMDYTITMYLNQYWRDERLQFIFNESLDLGENRSVTTMTLTGAFAEKIWVPDTFLANDKNSFLHDITEKNKMVRLYGNGSLVYGMRFTTTLACMMDLHNYPLDHQECTVEIESYGYTMDDIVLYWLNDRGAVTGVEDVSLPQFSITNYATINKIEELSTGDYQRLSLIFQLQRNIGYFIFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISNGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGARAKRKAKRLRERATSVRKRVDDGDQMNNTNMDTVELKEVHMVPTSVGVTNSQSFNLDLDDGSGDDTGFRVVPPIPRSFTHSHATTHGYIPTNVVRRRSSSHVPPRRRRLLSHFRQKAKSIKVKIPRVQDVNTIDKYARLMFPLLFIIFNTSYWSVYLLT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1002/j.1460-2075.1991.tb04887.x; 10.1042/bst0180438